Blood pressure and blood selenium: a cross-sectional and longitudinal population study
Key result
Higher blood selenium linked to ~37% lower hypertension risk in men.
- 37% lower risk
- 95% CI -52 to -17
- P=0.001
- n=710
Why the study?
Does higher blood selenium prevent the development of high blood pressure in a general population?
Population
710 subjects from a Flemish population, mean age 48.8 years, 51.8% women. Longitudinal analysis included 385…
Comparison
Higher blood selenium levels vs Lower blood selenium levels
Design
Cohort
Follow-up
5.2 years (range 3.4-8.4 years)
Authors
Discussion
Loading...
Member takes
Implication
Higher blood selenium levels are associated with a lower risk of developing high blood pressure in men, suggesting selenium deficiency may be an underestimated risk factor for hypertension.
Key Points
- This research aimed to evaluate the relationship between blood selenium levels and blood pressure in a Flemish population, both cross-sectionally and longitudinally.
- Randomly recruited 710 subjects with a mean age of 48.8 years.
- Measured blood pressure and blood selenium levels, conducting follow-up on blood pressure outcomes.
- Included multivariate-adjusted cross-sectional and prospective analyses.
- A 20 microg/L increase in blood selenium linked to a 2.2 mmHg decrease in systolic BP (P = 0.009).
- Men with higher baseline selenium showed a 37% lower risk (P = 0.001) of developing high-normal BP or hypertension over the follow-up period.
- No significant associations were found in women.
Study Design
Type
Observational (n=710)
Structured PICO
Does higher blood selenium prevent the development of high blood pressure in a general population?
P
Population
710 subjects from a Flemish population (mean age 48.8 years, 51.8% women) followed for an average of 5.2 years to assess the association between blood selenium and blood pressure.
E
Exposure
Higher blood selenium (BSe) levels (evaluated per 20 microg/L increase)
C
Comparator
Lower blood selenium levels
O
Outcome
Blood pressure levels (cross-sectional) and development of high-normal BP (130-139/85-90 mmHg) or hypertension (≥140/90 mmHg) over 5.2 yearssurrogate
Main Result
Effect estimate: 37% lower risk (95% CI -52 to -17)
p-value: p=0.001
Higher blood selenium levels are associated with a lower risk of developing high blood pressure in men, suggesting selenium deficiency may be an underestimated risk factor for hypertension.
Cite This Study
Nawrot et al. (2006) conducted an observational in Hypertension (n=710). Higher blood selenium levels vs. Lower blood selenium levels was evaluated on Development of high-normal BP (130-139/85-90 mmHg) or hypertension (≥140/90 mmHg) (37% lower risk, 95% CI -52 to -17, p=0.001). In men, a 20 μg/L higher baseline blood selenium was associated with a 37% lower risk of developing high-normal blood pressure or hypertension (95% CI -52 to -17; P=0.001).