August 1, 2001Journal of Hypertension
Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population
Key result
Epistatic interactions between ACE, ADD, and AS genes significantly influenced hypertension incidence, with ACE/DD homozygotes showing a 252% higher incidence among those with ADD/Trp and AS/CC genotypes (P=0.001).
Why the study?
Do epistatic interactions between the ACE, ADD, and AS genes influence the prevalence and incidence of hypertension in a Caucasian population?
Population
1461 subjects randomly selected from a Caucasian population, including a subgroup of 678 initially…
Comparison
Presence of specific genotypes and epistatic… vs Other genotypes or absence of specific risk…
Design
Cohort
Follow-up
median 9.1 years
Authors
Discussion
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Implication
Gene interactions may elevate hypertension risk in Caucasians; hypothesis-generating and requires prospective validation before clinical use.
Study Design
Type
Cohort (n=1,461)
Structured PICO
Do epistatic interactions between the ACE, ADD, and AS genes influence the prevalence and incidence of hypertension in a Caucasian population?
P
Population
1,461 subjects randomly selected from a Caucasian population, including a subgroup of 678 initially normotensive subjects followed for a median of 9.1 years.
E
Exposure
Presence of specific genotypes and epistatic interactions of ACE (I/D), alpha-adducin (ADD, Gly460Trp), and aldosterone synthase (AS, -344C/T) genes
C
Comparator
Other genotypes or absence of specific risk alleles within the same genes
O
Outcome
Blood pressure, plasma renin activity, urinary aldosterone, and incidence of hypertension
Main Result
Relative Risk: 1.29
p-value: p=0.05
Epistatic interactions between the ACE, ADD, and AS genes significantly contribute to the risk of developing hypertension in Caucasian populations.
Cite This Study
Staessen et al. (2001) conducted a cohort in Hypertension (n=1,461). ACE, ADD, and AS gene polymorphisms vs. Other genotypes was evaluated on Incidence of hypertension (RR 1.29, p=0.05). Epistatic interactions between ACE, ADD, and AS genes significantly influenced hypertension incidence, with ACE/DD homozygotes showing a 252% higher incidence among those with ADD/Trp and AS/CC genotypes (P=0.001).