Why the study?
Are adducin family gene polymorphisms (ADD1, ADD2, ADD3) associated with variations in ambulatory blood pressure, plasma renin activity, and endogenous ouabain in newly discovered, untreated hypertensive patients?
Population
512 newly discovered and never-treated hypertensive patients
Comparison
Mutated Trp ADD1 allele vs Wild type (Gly/Gly) ADD1 gene carriers
Design
Cross-sectional
Authors
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ADD1-ADD3 interaction was associated with higher BP in untreated hypertensives; hypothesis-generating and leaves open any role in risk stratification or therapy.
Are adducin family gene polymorphisms (ADD1, ADD2, ADD3) associated with variations in ambulatory blood pressure, plasma renin activity, and endogenous ouabain in newly discovered, untreated hypertensive patients?
The interaction between ADD1 and ADD3 gene variants is associated with significant variations in blood pressure in untreated hypertensive patients, suggesting epistatic effects among these loci.
Lanzani et al. (2005) studied this question.
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