December 1, 1997Journal of Hypertension
Alpha-adducin gene polymorphism and cardiovascular phenotypes in a general population
Why the study?
Is the Gly460Trp polymorphism of alpha-adducin associated with higher blood pressure, left ventricular mass, or carotid wall thickness in a general population?
Population
246 subjects randomly chosen from a middle-aged general population.
Comparison
Presence of the Trp460 allele of the Gly460Trp… vs Absence of the Trp460 allele
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Trp460 allele associated with hypertension risk; leaves open causal role, effects on remodeling, and any screening utility.
Structured PICO
Is the Gly460Trp polymorphism of alpha-adducin associated with higher blood pressure, left ventricular mass, or carotid wall thickness in a general population?
P
Population
246 subjects (124 men and 122 women, aged 57.7+/-3.7 years) randomly chosen from a middle-aged general population.
I
Intervention
Presence of the Trp460 allele of the Gly460Trp diallelic variant of human alpha-adducin
C
Comparator
Absence of the Trp460 allele
O
Outcome
24-hour ambulatory blood pressure, left ventricular mass (by echocardiography), and carotid wall thickness (by B-mode ultrasound)surrogate
The Trp460 allele of the alpha-adducin gene is associated with an increased risk of hypertension in a middle-aged general population, though it does not appear to significantly impact left ventricular mass or carotid wall thickness.
Limitations
- Small sample size requiring further investigation in larger and different population samples
Cite This Study
Castellano et al. (1997) studied this question.