Key result
The alpha-adducin Trp allele significantly increased the odds of hypertension in white subjects (OR 1.73; 95% CI 1.17-2.54; P=0.0056), but was not a significant independent predictor in black subjects.
Why the study?
Is the Gly460Trp mutation at the alpha-adducin locus associated with an increased risk of hypertension in white and black subjects?
Population
1,394 subjects from five geographically diverse field centers. Cases met JNC VI criteria for hypertension.
Comparison
Presence of the point mutation Gly460Trp at the… vs Absence of the Trp allele
Design
Case-control
Authors
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Alpha-adducin Trp allele was associated with hypertension in whites only; leaves open its utility for risk stratification pending prospective validation.
Case-Control (n=1,394)
Yes
Is the Gly460Trp mutation at the alpha-adducin locus associated with an increased risk of hypertension in white and black subjects?
Odds Ratio: 1.73 (95% CI 1.17–2.54)
p-value: p=0.0056
The alpha-adducin Gly460Trp mutation is a significant, independent risk factor for hypertension in white subjects, particularly those with specific risk factor profiles, but not in black subjects.
Province et al. (2000) conducted a case-control in hypertension (n=1,394). alpha-adducin gene point mutation Gly460Trp (Trp allele) vs. Absence of Trp allele was evaluated on hypertension (OR 1.73, 95% CI 1.17-2.54, p=0.0056). The alpha-adducin Trp allele significantly increased the odds of hypertension in white subjects (OR 1.73; 95% CI 1.17-2.54; P=0.0056), but was not a significant independent predictor in black subjects.
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