Key result
The alpha-adducin 460Trp allele showed no statistically significant association with hypertension risk compared to the Gly460 allele (OR 1.02, 95% CI 0.94-1.10, P=0.69).
Why the study?
Does the alpha-adducin Gly460Trp polymorphism increase the risk of essential hypertension?
Population
30,264 subjects from 22 studies, including Caucasians, East Asians, and others
Comparison
Presence of the alpha-adducin 460Trp allele vs Presence of the alpha-adducin Gly460 allele
Design
Meta-analysis
Authors
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No association with hypertension risk; leaves open contributions from other variants or interactions in essential hypertension.
Meta-Analysis (n=30,264)
Does the alpha-adducin Gly460Trp polymorphism increase the risk of essential hypertension?
Effect estimate: OR 1.02 (95% CI 0.94-1.10)
Absolute Event Rate: 34.91% vs 35.23%
p-value: p=0.69
This meta-analysis found no significant association between the alpha-adducin Gly460Trp polymorphism and the risk of essential hypertension.
Liu et al. (2010) conducted a meta-analysis in Essential hypertension (n=30,264). Alpha-adducin 460Trp allele vs. Gly460 allele was evaluated on Hypertension risk (OR 1.02, 95% CI 0.94-1.10, p=0.69). The alpha-adducin 460Trp allele showed no statistically significant association with hypertension risk compared to the Gly460 allele (OR 1.02, 95% CI 0.94-1.10, P=0.69).
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