Why the study?
Is the Gly460Trp polymorphism of the alpha-adducin gene associated with hypertension and plasma renin activity in Japanese subjects?
Population
283 Japanese subjects enrolled at an outpatient clinic, divided into normotensive, borderline, and…
Comparison
Presence of the Gly460Trp polymorphism of the… vs Absence of the polymorphism (GG genotype)
Design
Cross-sectional
Authors
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Hypothesis-generating for alpha-adducin in Japanese hypertension; prospective studies needed before genotyping or renin-guided therapy.
Is the Gly460Trp polymorphism of the alpha-adducin gene associated with hypertension and plasma renin activity in Japanese subjects?
The Gly460Trp polymorphism of the alpha-adducin gene is associated with hypertension and lower plasma renin activity in Japanese individuals.
Tamaki et al. (1998) studied this question.
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