June 1, 2000American Journal of Hypertension
-adducin polymorphism in hypertensives of South African ancestry
Why the study?
Does the 460-Trp variant of the alpha-adducin gene increase the risk of hypertension in black South Africans?
Population
Black South Africans (hypertensives and normotensives)
Comparison
460-Trp variant of the alpha-adducin gene vs Normotensive controls / non-carriers
Design
Case-control
Authors
Discussion
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Member takes
Implication
Should not change practice; leaves open ethnic-specific genetic associations pending replication.
Structured PICO
Does the 460-Trp variant of the alpha-adducin gene increase the risk of hypertension in black South Africans?
P
Population
Black South Africans (hypertensives and normotensives)
I
Intervention
460-Trp variant of the alpha-adducin gene
C
Comparator
Normotensive controls / non-carriers
O
Outcome
Association with hypertension
Despite a low overall frequency, the 460-Trp variant of the alpha-adducin gene is significantly associated with hypertension in black South Africans, highlighting ethnic variability in hypertension genetics.
Cite This Study
Barlassina et al. (2000) studied this question.