Key result
Hypertensive patients carrying at least one Trp460 allele of the α-adducin gene had significantly higher systolic blood pressure responses at peak exercise and recovery (P=0.036).
Why the study?
Does carrying the Trp460 allele of the α-adducin gene increase blood pressure response to exercise in hypertensive patients?
Cross-Sectional (n=49)
Does carrying the Trp460 allele of the α-adducin gene increase blood pressure response to exercise in hypertensive patients?
Hypertensive patients carrying the Trp460 allele of the α-adducin gene exhibit a significantly higher systolic blood pressure response to exercise.
Trp460 allele carriage was associated with higher exercise systolic BP; hypothesis-generating and requires prospective validation before clinical consideration.
OBJECTIVE: Clinical studies have indicated that an excessive response of blood pressure (BP) to exercise predicts risk of cardiovascular mortality. Although the mechanism responsible for the excessive BP response to exercise has not been revealed, there are some plausible mechanisms linking with underlying structural abnormalities in the cardiovascular system. Carriers of the Trp460 allele of the α-adducin Gly460Trp polymorphism have an increased risk of hypertension. The aim of the present study was to examine the influence of α-adducin gene polymorphism on response of BP to exercise in patients with hypertension. METHODS: The cross-sectional observational study consisted of 49 hypertensive patients (29 women and 20 men; mean age, 53.1±8.8 years). All participants underwent a multistage exercise treadmill test according to the Bruce protocol. Arterial BPs were compared at rest, peak exercise and end of the recovery phase. Patients were classified according to their α-adducin gene polymorphisms; Gly460Gly homozygotes - Group 1 (n=28) and Trp460Trp homozygotes and Gly460Trp heterozygotes - Group 2 (n=21). Statistical analysis was performed using Chi-square, unpaired t, Mann-Whitney U and ANCOVA tests. RESULTS: Mean exercise duration and mean exercise capacity in metabolic equivalents were not different between Group 1 and 2. The major finding of the study was that systolic BP responses at peak exercise and recovery period (3. min) were significantly higher (p=0.036) in hypertensive patients carrying at least one Trp460 allele of the α-adducin gene. CONCLUSION: Our results suggest that genetic variants that alter renal function and/or vasoreactivity are logical candidates to explain some of the individual variability in the BP response to exercise.
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Alioğlu et al. (2010) conducted a cross-sectional in hypertension (n=49). Trp460 allele of the α-adducin gene vs. Gly460Gly homozygotes was evaluated on systolic BP responses at peak exercise and recovery period (p=0.036). Hypertensive patients carrying at least one Trp460 allele of the α-adducin gene had significantly higher systolic blood pressure responses at peak exercise and recovery (P=0.036).
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