Key result
Older age linked to ~2% greater atrial fibrillation risk per year in CHD patients.
Why the study?
Atrial arrhythmias are the most common complication in the aging congenital heart disease population, but types, patterns, associated factors, and age-related trends needed assessment.
Cohort (n=482)
Blinded adjudication
Yes
Odds Ratio: 1.024 (95% CI 1.01–1.039)
p-value: p=0.001
In patients with congenital heart disease, intra-atrial re-entrant tachycardia is the most common presenting atrial arrhythmia, but atrial fibrillation and permanent arrhythmias become increasingly prevalent with advancing age.
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Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“Atrial fibrillation increases in prevalence and atrial arrhythmias progressively become permanent as the population ages.”
Maps arrhythmia patterns in congenital heart disease; leaves open targeted therapies pending prospective trials.
Labombarda et al. (2017) conducted a cohort in Congenital heart disease and atrial arrhythmias (n=482). Older age vs. Younger age was evaluated on Atrial fibrillation (OR 1.024, 95% CI 1.010-1.039, p=0.001). Older age was independently associated with atrial fibrillation in patients with congenital heart disease (OR 1.024 per year; 95% CI 1.010-1.039; P=0.001).
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