Atrial tachyarrhythmia is a reversible cause of increased atrial FDG uptake on PET/CT and should be correlated with ECG to avoid misdiagnosis of cardiac disease.
We report a case of marked biatrial 18 F-FDG uptake on PET/CT coinciding with the onset of symptomatic atrial flutter in a 77-year-old man with relapsed diffuse large B-cell lymphoma receiving ibrutinib. Serial imaging demonstrated normal atrial uptake before arrhythmia, marked uptake during atrial flutter, and complete normalisation following successful radiofrequency ablation. Atrial tachyarrhythmia represents an important and reversible cause of increased atrial FDG uptake and should prompt clinical and electrocardiographic correlation to avoid misinterpretation as cardiac disease involvement.
Jeffrey et al. (Mon,) studied this question.