Key result
Unstable angina is linked to a lower PMN apoptotic rate versus stable angina and healthy controls.
Why the study?
To investigate spontaneous polymorphonuclear neutrophil apoptosis in unstable angina and its association with recurrence of instability.
Is delayed polymorphonuclear neutrophil apoptosis associated with unstable angina and recurrence of instability?
Observational (n=100)
Is delayed polymorphonuclear neutrophil apoptosis associated with unstable angina and recurrence of instability?
p-value: p=<0.01
Delayed PMN apoptosis is observed in unstable angina and is associated with higher hs-CRP levels and early recurrence of symptoms, suggesting a role in persistent inflammatory activation.
Delayed PMN apoptosis may flag recurrence risk in UA; leaves open whether targeting apoptosis alters outcomes.
AIMS: To investigate spontaneous polymorphonuclear neutrophils (PMNs) apoptosis in unstable angina (UA) and its association with recurrence of instability. METHODS AND RESULTS: We compared PMNs apoptotic rate at 4 and 24 h in patients with UA, stable angina (SA), and controls (H) with two different protocols by flow cytometry. We measured apoptotic rate of isolated PMNs (Protocol 1) in 30 UA patients, 13 SA patients, and 34 H; and apoptosis of PMNs in whole blood culture (Protocol 2) in further 10 UA patients, 7 SA patients, and 6 H. Serum high-sensitivity C-reactive protein was also measured. Polymorphonuclear neutrophils of UA patients showed a decreased apoptotic rate compared with SA patients and H at 4 h in Protocol 1 (both P < 0.01), and at 24 h in Protocol 2 (P < 0.05 and <0.01, respectively). In overall population, a negative correlation was found between apoptotic rate at 4 h and high-sensitivity C-reactive protein levels (P < 0.01). Six among 40 patients with UA had early recurrence of symptoms and their apoptotic rate was significantly reduced compared with UA patients without recurrence of symptoms (P = 0.024). CONCLUSIONS: Our study demonstrates delayed PMN apoptosis in UA. This alteration might be involved in the persistence of inflammatory activation and affects recurrence of instability.
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Biasucci et al. (2009) conducted an observational in Unstable angina (n=100). Unstable angina vs. Stable angina and healthy controls was evaluated on Polymorphonuclear neutrophil apoptotic rate at 4 and 24 hours (p=<0.01). Unstable angina was associated with a significantly decreased polymorphonuclear neutrophil apoptotic rate compared with stable angina and healthy controls (P<0.01).
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