Key result
Congestive heart failure was associated with significantly decreased circulating PMN and monocyte TNF receptor levels and a 60% decrease in spontaneous PMN apoptosis compared to patients without CHF.
Why the study?
Are systemic immune cell proinflammatory receptor expression and apoptosis altered in patients with congestive heart failure compared to those with coronary artery disease without heart failure?
Population
29 patients studied prospectively at a single institution, including 16 with clinical symptoms of congestive…
Design
Cohort
Follow-up
8-month period
Authors
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May indicate systemic immune dysregulation in CHF; leaves open prognostic or therapeutic utility.
Observational (n=29)
No
Are systemic immune cell proinflammatory receptor expression and apoptosis altered in patients with congestive heart failure compared to those with coronary artery disease without heart failure?
Patients with congestive heart failure exhibit systemic alterations in immune cell phenotype, including decreased TNF receptor expression and diminished spontaneous PMN apoptosis, which may serve as biologic markers of myocardial failure.
Rumalla et al. (2002) conducted an observational in Congestive heart failure (n=29). Congestive heart failure vs. Patients without congestive heart failure was evaluated on Systemic immune cell proinflammatory receptor expression and apoptosis. Congestive heart failure was associated with significantly decreased circulating PMN and monocyte TNF receptor levels and a 60% decrease in spontaneous PMN apoptosis compared to patients without CHF.
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