Key result
Elevated IL-6 linked to ~6.7-fold higher mortality in chronic heart failure.
Why the study?
Are peripheral blood concentrations of proinflammatory cytokines elevated in patients with chronic heart failure compared to normal controls?
Population
Patients with chronic heart failure (CHF) and normal control subjects from 28 included studies
Comparison
Assessment of proinflammatory cytokines in… vs Normal control subjects
Design
Meta-analysis
Authors
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Elevated IL-6 may flag higher mortality risk in chronic heart failure; leaves open whether targeting it alters outcomes.
Meta-Analysis
Are peripheral blood concentrations of proinflammatory cytokines elevated in patients with chronic heart failure compared to normal controls?
Effect estimate: OR 6.73 (95% CI 2.39-18.93)
p-value: p=0.0003
Proinflammatory cytokines including TNF-α, IL-6, IL-1β, and CRP are significantly elevated in patients with chronic heart failure, supporting their role in its pathogenesis.
Liu et al. (2014) conducted a meta-analysis in Chronic heart failure. Elevated IL-6 vs. Control group was evaluated on Mortality (OR 6.73, 95% CI 2.39-18.93, p=0.0003). Elevated IL-6 levels in patients with chronic heart failure were associated with significantly higher mortality compared to the control group (OR 6.73; 95% CI 2.39-18.93; p=0.0003).
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