Key result
Elderly men with moderate heart failure had similar levels of TNF (p=0.27), NK activity (p=0.56), and lymphocyte mitogenesis (p=0.67) compared to age-matched controls.
Why the study?
Are tumor necrosis factor (TNF) and other measures of immunity and inflammation elevated in elderly men with chronic heart failure compared to controls?
Population
37 elderly men, comprising 20 with New York Class II and III heart failure and 17 age-matched controls.
Design
Cross-sectional
Authors
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Similar levels do not support TNF monitoring in moderate HF; hypothesis-generating for subclinical activation via interrelationships.
Cross-Sectional (n=37)
No
Are tumor necrosis factor (TNF) and other measures of immunity and inflammation elevated in elderly men with chronic heart failure compared to controls?
p-value: p=0.27
In elderly men with moderate heart failure, absolute levels of TNF and immune markers are not significantly elevated compared to controls, but their interrelationships suggest the presence of subclinical immune activation.
Pritchett et al. (2009) conducted a cross-sectional in Chronic heart failure (n=37). Chronic heart failure vs. Age-matched controls without heart failure was evaluated on Levels of lymphocyte mitogenesis, TNF, natural killer (NK) cell activity, elastase-alpha 1-antitrypsin (E/alpha) and cross-linked fibrin D-dimers (XDP) (p=0.27). Elderly men with moderate heart failure had similar levels of TNF (p=0.27), NK activity (p=0.56), and lymphocyte mitogenesis (p=0.67) compared to age-matched controls.
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