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October 21, 2008The World Journal of Biological Psychiatry

Mood, Th-1/Th-2 cytokine profile, and autonomic activity in older adults with acute/decompensated heart failure: Preliminary observations

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Population

20 consecutive older patients admitted to the coronary care unit with a clinical diagnosis of…

Design

Cross-sectional

Authors

SGSalvador M. GuinjoanTulsa Community CollegeDVDaniel E. VigoPontificia Universidad Católica ArgentinaMCMariana N. CastroInstituto de Neurología Cognitiva

Discussion

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Implication

Links depression, HRV, and inflammation in decompensated HF; hypothesis-generating, leaves open causality and clinical relevance.

Structured PICO

P
Population
20 consecutive older patients (mean age 78+/-7 years, 35% women) admitted to the coronary care unit with a clinical diagnosis of acute/decompensated heart failure of coronary origin.
O
Outcome
Relationships among mood (assessed by 21-item Hamilton Depression Scale), peripheral autonomic output (Heart rate variability), and circulating immunoinflammatory mediators (TNF-alpha, IFN-gamma, IL-2, IL-4, IL-6, IL-10) measured within 24-72 h of admission.surrogate

In older adults with decompensated heart failure, worse mood and autonomic imbalance are associated with increased systemic inflammation, suggesting a potential mechanism for mood-related worsened prognosis.

Cite This Study

Guinjoan et al. (2008) studied this question.

synapsesocial.com/papers/6a724cc435aa2c282ce32f8chttps://doi.org/10.1080/15622970802432153
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac-related Hospitalization and/or Death Associated With Immune Dysregulation and Symptoms of Depression in Heart Failure Patients2007 · 45 citations
  2. 2Depressive Symptoms Are Related to Decreased Low-Frequency Heart Rate Variability in Older Adults with Decompensated Heart Failure2007 · 27 citations
  3. 3Associations between Major Depression, Bipolar Disorders, Dysthymia and Cardiovascular Diseases in the General Adult Population2006 · 85 citations
  4. 4Cardiac Electrophysiology: From Cell to Bedside1991 · 2,392 citations
  5. 5Neuroimmunoendocrinology of the cervical autonomic nervous system1998 · 23 citations