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January 1, 2007Psychosomatic Medicine

Cardiac-related Hospitalization and/or Death Associated With Immune Dysregulation and Symptoms of Depression in Heart Failure Patients

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Why the study?

Are depressive symptoms and altered Th1/Th2 ratios associated with increased risk of cardiac rehospitalization or death in patients with congestive heart failure?

Population

18 patients with congestive heart failure (NYHA classes II-IV), mean age 62.

Design

Cohort

Follow-up

two years

Authors

LRLaura RedwineCross-Cutting CardiologyPMPaul J. MillsSupélecSHSuzi HongU.S. National Science Foundation

Discussion

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Implication

May aid risk stratification in CHF; leaves open whether targeting depression or Th1/Th2 imbalance improves outcomes.

Structured PICO

Are depressive symptoms and altered Th1/Th2 ratios associated with increased risk of cardiac rehospitalization or death in patients with congestive heart failure?

P
Population
18 patients with congestive heart failure (NYHA classes II-IV), mean age 62.
O
Outcome
Cardiac related rehospitalization or cardiac related death over a two-year periodcomposite

In a small cohort of CHF patients, depressive symptoms and a shift in Th1/Th2 ratios were associated with increased morbidity and mortality, suggesting a role for broader immune dysregulation.

Cite This Study

Redwine et al. (2007) studied this question.

synapsesocial.com/papers/6a71e24835aa2c282ce2fb60https://doi.org/10.1097/psy.0b013e31802e2f35

Topics

Heart failureHFrEF treatmentHeart failure hospitalization
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Also Consider

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