Key result
Tumor necrosis factor alpha concentrations were significantly higher in patients with chronic heart failure compared to control subjects (20.0 vs 18.0 pg/mL, p<0.05).
Why the study?
Are circulating cytokines and complements elevated in patients with chronic heart failure and do they correlate with mortality?
Population
60 subjects with chronic heart failure; 34 with idiopathic dilated cardiomyopathy and 26 with ischemic heart…
Comparison
Assessment of circulating cytokines and… vs Control subjects
Design
Cohort
Authors
Loading...
TNF-α elevation in chronic heart failure supports immune dysregulation hypothesis; leaves open prognostic value and therapeutic targeting.
Observational (n=60)
Are circulating cytokines and complements elevated in patients with chronic heart failure and do they correlate with mortality?
Absolute Event Rate: 20% vs 18%
p-value: p=<0.05
Elevated circulating cytokines and complements in chronic heart failure suggest that humoral and cellular immunity abnormalities may play a role in its pathogenesis and have independent prognostic value for mortality.
Koşar et al. (1999) conducted an observational in Chronic heart failure (n=60). Chronic heart failure vs. Control subjects was evaluated on Tumor necrosis factor alpha concentration (pg/mL) (p=<0.05). Tumor necrosis factor alpha concentrations were significantly higher in patients with chronic heart failure compared to control subjects (20.0 vs 18.0 pg/mL, p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: