Key result
Elevated sTNF-RI and sIL-1Ra strongly correlate with worse exercise capacity in heart failure.
Why the study?
The pathophysiologic role of cytokine inhibitors in advanced cardiac disease remains unclear.
Population
11 patients with severe chronic congestive heart failure and 11 healthy volunteers
Comparison
Heart failure patients vs healthy volunteers
Design
Observational study
Authors
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Elevated cytokine inhibitor levels in severe HF may mark disease activity; leaves open their causal role or therapeutic targeting in larger prospective studies.
Observational (n=22)
p-value: p=0.01
Missov et al. (1997) conducted an observational in Severe chronic congestive heart failure (n=22). Serum cytokine inhibitors vs. Healthy volunteers was evaluated on Serum concentrations of cytokine inhibitors and association with symptom-limited oxygen consumption (p=0.01). Serum levels of sTNF-RI and sIL-1 Ra were significantly increased in heart failure patients and strongly inversely associated with symptom-limited oxygen consumption (R=-0.68, p=0.04 and R=-0.77, p=0.01).
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