Key result
Patients with LV dysfunction exhibit ~19% lower circulating IFN-γ and higher IL-6 versus healthy controls.
Population
44 patients with left ventricular dysfunction, mean age 61, male to female ratio 6.33, and 29 healthy…
Design
Case-control
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Supports further investigation of cytokine imbalances in LV dysfunction; should not yet alter clinical management.
Case-Control (n=73)
No
Absolute Event Rate: 180.2% vs 223.74%
p-value: p=0.019
Patients with left ventricular dysfunction exhibit significantly lower levels of IFN-γ and higher levels of IL-6 compared to healthy controls, suggesting a potential role for interferon modulation in heart failure.
A 2018 study conducted a case-control in Left ventricular dysfunction / Heart failure (n=73). Left ventricular dysfunction vs. Healthy controls was evaluated on Circulating IFN-γ levels (pg/ml) (p=0.019). Patients with left ventricular dysfunction exhibited significantly lower levels of circulating IFN-γ (180.20 vs 223.74 pg/ml) and higher levels of IL-6 compared to healthy controls.
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