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April 1, 2005Annals of MedicineOpen Access

Inflammatory and anti‐inflammatory cytokines in chronic heart failure: Potential therapeutic implications

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Why the study?

Does immunomodulatory therapy improve outcomes in patients with chronic heart failure?

Population

Patients with chronic heart failure

Comparison

Immunomodulatory therapy vs Placebo

Design

Review

Authors

PAPål AukrustHeart Failure & TransplantLGLars GullestadHeart Failure & TransplantTUThor UelandHeart Failure & Transplant

Discussion

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Implication

Anti-TNF therapy lacks support in heart failure; leaves open targeted cytokine modulation for future trials.

Structured PICO

Does immunomodulatory therapy improve outcomes in patients with chronic heart failure?

P
Population
Patients with chronic heart failure
I
Intervention
Immunomodulatory therapy (including anti-tumor necrosis factor therapy)
C
Comparator
Placebo
O
Outcome
Cardiac performance and clinical improvement

Despite the pathogenic role of inflammation in chronic heart failure, current anti-TNF therapies have not shown clinical benefit, highlighting the need for more specific immunomodulating agents.

Cite This Study

Aukrust et al. (2005) studied this question.

synapsesocial.com/papers/6a2bc787ee61e29454f8636fhttps://doi.org/10.1080/07853890510007232

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Expression of Interleukin-1β and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Hypertrophied and Failing Heart With Pressure Overload1997 · 163 citations
  2. 2Evidence for a Role of Mast Cells in the Evolution to Congestive Heart Failure2002 · 240 citations
  3. 3Intravenous Immune Globulin in the Therapy of Myocarditis and Acute Cardiomyopathy1997 · 241 citations
  4. 4Impact of HMG CoA reductase inhibition on small GTPases in the heart2002 · 202 citations
  5. 5The role of tumor necrosis factor in the pathophysiology of heart failure2000 · 510 citations