Why the study?
Is the lifespan of circulating polymorphonuclear neutrophils increased in patients with congestive heart failure compared to controls?
Population
55 subjects, comprising 29 patients with congestive heart failure (CHF) and 26 controls.
Design
Case-control
Authors
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May implicate delayed neutrophil apoptosis in CHF inflammation; hypothesis-generating and should not yet change practice.
Is the lifespan of circulating polymorphonuclear neutrophils increased in patients with congestive heart failure compared to controls?
Patients with congestive heart failure exhibit delayed neutrophil apoptosis, which correlates with disease severity and endothelial damage, suggesting a mechanism for persistent inflammation.
Tracchi et al. (2009) studied this question.
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