Why the study?
Data on neutrophil status in heart failure with reduced ejection fraction are scarce, prompting an evaluation of neutrophil CD11b, CD66b, and CD64 expression in HFrEF.
Population
135 HFrEF patients and 43 controls
Comparison
HFrEF patients vs controls
Key result
Neutrophil CD64 expression was higher in HFrEF patients compared with controls, and CD11b and CD66b correlated inversely with heart failure severity, but none were associated with mortality.
Authors
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May support neutrophil phenotyping in HFrEF; leaves open prognostic utility pending prospective validation.
Observational (n=178)
p-value: p=ns
Neutrophil activation markers are altered in HFrEF, with CD64 elevated and CD11b/CD66b inversely correlating with disease severity, suggesting a role for neutrophil-mediated inflammation in heart failure pathophysiology.
Prausmüller et al. (2022) conducted an observational in Heart failure with reduced ejection fraction (HFrEF) (n=178). Heart failure with reduced ejection fraction vs. Controls was evaluated on All-cause mortality (p=ns). Neutrophil CD64 expression was higher in HFrEF patients compared with controls, and CD11b and CD66b correlated inversely with heart failure severity, but none were associated with mortality.
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