Key result
In patients with chronic HFrEF, NYHA functional class correlated significantly with mean platelet volume (r = 0.311, p = 0.0001) and altered leukocyte counts.
Why the study?
Inflammation regulates thrombosis complications in chronic heart failure, but the relationship between platelet activity and cell count readings across NYHA functional classes in HFrEF required evaluation.
Observational (n=185)
Effect estimate: r = 0.311
p-value: p=0.0001
Mean platelet volume and inflammatory cell counts correlate with NYHA functional class in HFrEF, suggesting a link between heart failure severity, inflammation, and hypercoagulability.
NYHA class correlation with platelet volume in HFrEF is hypothesis-generating; requires prospective validation before any clinical use.
Background and objectives: There has been an increasing interest in the role of inflammation in thrombosis complications in chronic heart failure (HF) patients. The incidence of thrombosis in HF has been shown to be the highest in patients classified as NYHA IV (New York Heart association). It is stated that inflammation is regulated by platelet-induced activation of blood leukocytes. We aimed to compare the platelet and cell count readings in chronic HF with reduced ejection fraction (HFrEF) patients according to NYHA functional class and to evaluate the correlation between those readings. Materials and methods: A total of 185 patients were examined. The results of heart echoscopy (TEE) testing; fibrinogen, N-terminal pro b-type natriuretic peptide (NT-proBNP), C reactive protein (CRP), and cortisol concentrations; complete blood counts; and a 6 min walking test were assessed and platelet aggregation was determined. Results: Mean platelet volume (MPV) increased with deterioration of a patient’s state (p < 0.005). Lymphocyte count and percentage were the lowest in the NYHA IV group (p < 0.005). Neutrophil and monocyte percentage and count were the highest (p < 0.045) in the NYHA IV group. Adenosine diphosphate (ADP)- and ADR-induced platelet aggregation was higher in the NYHA III group compared to NYHA II and I groups (p < 0.023). NYHA functional class correlated with mean platelet volume (MPV) (r = 0.311, p = 0.0001), lymphocyte count (r = −0.186, p = 0.026), monocyte count (p = 0.172, p = 0.041), and percentage (r = 0.212, p = 0.011). CRP concentration correlated with NT-proBNP (r = 0.203, p = 0.005). MPV correlated with fibrinogen concentration (r = 0.244, p = 0.004). Conclusions: (1) MPV could be considered as an additional reading reflecting a patient’s condition, however the use of MPV to identify patients at risk of hypercoagulable state should be evaluated in more extensive studies; (2) increased neutrophil and monocyte counts could indicate a higher inflammatory state in chronic HFrEF.
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Mongirdienė et al. (2021) conducted an observational in Chronic heart failure with reduced ejection fraction (HFrEF) (n=185). NYHA functional class vs. Lower NYHA functional classes was evaluated on Correlation of NYHA functional class with mean platelet volume (MPV) (r = 0.311, p=0.0001). In patients with chronic HFrEF, NYHA functional class correlated significantly with mean platelet volume (r = 0.311, p = 0.0001) and altered leukocyte counts.
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