Key result
Coagulation parameters correlate with higher BNP, worse NYHA class, and lower LVEF in dilated cardiomyopathy.
Observational
No
Coagulation pathway parameters (PT, PTT, INR, d-dimer) correlate significantly with disease severity markers (BNP, NYHA class, EF) in patients with dilated non-ischemic cardiomyopathy.
Coagulation markers may complement severity assessment in dilated cardiomyopathy; leaves open prognostic value and therapeutic implications pending prospective data.
Background The upregulation of inflammation and coagulation in addition to the sympathetic nervous system is known and reported in congestive heart failure. This study was undertaken to assess the correlations of the changes in coagulation parameters with functional class, ejection fraction and brain natriuretic peptide levels. Methods A small prospective study was conducted in dilated cardiomyopathy (DCM) patients. The protocol was approved by the Hospital IRB ( Scott and White Memorial, Temple, TX 76508). Statistical analysis was conducted using the online Vassar stats system . Spearman’s rank order correlation was derived for all the correlations mentioned in this paper. Results PT, PTT, INR and d-dimer levels were significantly different in the two groups and correlated positively and significantly with BNP and New York Heart Association class . Statistically significant negative correlation was noted with ejection fraction. fibrinogen levels did not correlate significantly with BNP, New York Heart Association class or ejection fraction. Conclusions Coagulation pathway parameters correlate significantly with BNP, functional class and ejection fraction in this study. The study is limited by its size and the fact that only dilated non- ischemic cardiomyopathy patients were included. Larger studies are required to further understand the complex interactions of biochemical pathways noted in heart failure.
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Nair et al. (2016) conducted an observational in Dilated cardiomyopathy. Coagulation pathway parameters was evaluated on Correlation of coagulation parameters with BNP, NYHA class, and ejection fraction. Coagulation parameters (PT, PTT, INR, d-dimer) correlated positively with BNP and NYHA class, and negatively with ejection fraction in patients with dilated cardiomyopathy.
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