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January 9, 2013Electronic Journal of General MedicineOpen Access

Heart Failure: Discrepancy Between NYHA Functional Classification, Serum NT-pro Brain Natriuretic Peptide and Ejection Fraction

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Key result

NT-proBNP inversely correlates with EF but fails to match NYHA class in HF patients.

  • r = -0.339
  • P<0.001
  • n=193

Population

Patients with known cases of congestive heart failure and healthy subjects serving as a control group

Design

Cross-sectional

Authors

MAMarwan S.M. Al-NimerMustansiriyah UniversityAAAdil Hassan AlhusseinyUniversity of DiyalaILIsmail Ibrahim LatifUniversity of Diyala

Discussion

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Implication

Findings from single modalities may diverge in HF assessment; leaves open the value of multimodal integration in prospective cohorts.

Study Design

Type

Cross-Sectional (n=193)

Multicenter

No

Structured PICO

P
Population
193 participants, including 169 patients with treated congestive heart failure and 24 healthy controls, evaluated cross-sectionally to compare NT-proBNP levels with NYHA class and ejection fraction.
O
Outcome
Discrepancy between laboratory investigation (serum NT-proBNP), electrophysiological assessment (echocardiogram and Doppler study for ejection fraction), and clinical assessment (NYHA functional classification)surrogate

Main Result

Effect estimate: r = -0.339

p-value: p=< 0.001

Limitations

  • Associated risk factors
  • Variable etio-pathological factors of heart failure
  • Anti-heart failure medications

Cite This Study

Al-Nimer et al. (2013) conducted a cross-sectional in Congestive heart failure (n=193). Serum NT-proBNP vs. Healthy subjects was evaluated on Correlation between serum NT-proBNP and ejection fraction (r = -0.339, p=< 0.001). Serum NT-proBNP levels were significantly inversely correlated with ejection fraction (r = -0.339, p < 0.001) but did not match the NYHA functional classification in patients with heart failure.

synapsesocial.com/papers/6aa81728bfbaf8fff0574b60https://doi.org/10.29333/ejgm/82363

Topics

Heart failureHFrEF treatmentHeart failure hospitalization
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Also Consider

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