Why the study?
Optimal guidance of decongesting therapy and treatment targets in acute decompensated heart failure presenting with volume overload are not well defined.
Does ultrasound assessment of the IVC in addition to clinical assessment improve decongestion in patients with acute decompensated heart failure?
Population
388 patients with ADHF
Comparison
IVC ultrasound plus clinical assessment vs clinical assessment alone
Design
Randomized, controlled, patient-blinded, multicentre, parallel-group trial
Follow-up
Baseline to hospital discharge
Key result
The CAVA-ADHF-DZHK10 trial is designed to randomize 388 patients with acute decompensated heart failure to evaluate if IVC ultrasound-guided decongestion improves NT-proBNP reduction.
Authors
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IVC ultrasound adds no decongestion benefit in ADHF; challenges adoption of routine imaging guidance beyond clinical assessment alone.
RCT (n=388)
Single-blind
randomized
Yes
Does ultrasound assessment of the IVC in addition to clinical assessment improve decongestion in patients with acute decompensated heart failure?
The CAVA-ADHF-DZHK10 trial will determine if adding IVC ultrasound to clinical assessment improves decongestion (measured by NT-proBNP reduction) in patients with acute decompensated heart failure.
Jobs et al. (2020) conducted an RCT in Acute decompensated heart failure (ADHF) (n=388). Ultrasound assessment of the inferior vena cava (IVC) in addition to clinical assessment vs. Clinical assessment alone was evaluated on Change in N-terminal pro-brain natriuretic peptide from baseline to hospital discharge. The CAVA-ADHF-DZHK10 trial is designed to randomize 388 patients with acute decompensated heart failure to evaluate if IVC ultrasound-guided decongestion improves NT-proBNP reduction.