Key result
Incorporation of a generic memory current into simulated ventricular tissue spontaneously converted multiple wavelet fibrillation to mother rotor fibrillation due to progressive acceleration of rotors.
Computational modeling demonstrates that short-term cardiac memory can explain the initiation and stabilization of mother rotor fibrillation in heterogeneous tissue.
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Short-term memory may promote mother rotor VF in heterogeneous tissue; leaves open its role in human arrhythmias pending validation.
Baher et al. (2006) studied Fibrillation. Generic memory current in action potential model vs. Model lacking short-term memory was evaluated on Conversion of multiple wavelet fibrillation to mother rotor fibrillation. Incorporation of a generic memory current into simulated ventricular tissue spontaneously converted multiple wavelet fibrillation to mother rotor fibrillation due to progressive acceleration of rotors.
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