April 1, 1997AJP Heart and Circulatory Physiology
Memory and complex dynamics in cardiac Purkinje fibers
Population
Canine cardiac Purkinje fibers
Comparison
Constant and rapid pacing protocols vs Standard restitution protocol
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No clinical implications yet; leaves open APD memory role in human Purkinje fiber chaos.
Structured PICO
P
Population
Canine cardiac Purkinje fibers
I
Intervention
Constant and rapid pacing protocols
C
Comparator
Standard restitution protocol
O
Outcome
Complex cellular electrophysiological behavior, specifically the relationship between time to full repolarization (TFR) and diastolic interval (DI)surrogate
Rapid accumulation and dissipation of action potential duration memory contribute importantly to complex electrical behavior and chaos in cardiac Purkinje fibers.
Cite This Study
Gilmour et al. (1997) studied this question.