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Reveals enhanced tumor suppression in aggressive thyroid carcinoma using targeted nanotherapy, suggesting a new treatment approach.
Aims Aggressive papillary thyroid carcinoma (PTC) is often refractory to radioiodine therapy, and effective targeted therapeutic strategies are urgently needed. This study aimed to construct an AS1411 aptamer-guided gold nanoparticle drug delivery system loaded with doxorubicin (AS1411/AuNPs/Dox) for targeted synergistic therapy of PTC.Materials and methods The nanoplatform was synthesized and characterized by transmission electron microscopy, dynamic light scattering and Ultraviolet-Visible (UV-Vis) spectrometry. In vitro cellular uptake, cytotoxicity and drug release assays were performed, and in vivo antitumor efficacy and biosafety were evaluated in TPC-1 xenograft mouse models.Results The AS1411/AuNPs/Dox system exhibited good monodispersity, stability and dual pH/near-infrared (NIR) responsive doxorubicin release. AS1411-mediated targeting enabled selective enrichment and enhanced cytotoxicity in nucleolin-high TPC-1 cells. Combined chemo-photothermal therapy significantly suppressed tumor growth in vivo with no obvious systemic toxicity, and the antitumor effect was associated with regulation of mitochondrial apoptosis-related genes.Conclusions This multifunctional targeted nanoplatform exerts potent synergistic antitumor efficacy against aggressive PTC with good biosafety, providing a promising novel therapeutic strategy for radioiodine-refractory PTC.
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Wang et al. (2026) studied this question.
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