A Novel Polysaccharide from Walnut Dregs: Structural Features and Immunomodulatory Effects via Activation of MAPK Signaling Pathway

June 23, 2026FoodsOpen Access

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Key Points

This research aims to explore the structural characteristics and immunomodulatory effects of a polysaccharide extracted from walnut dregs.
Purification and structural analysis of a novel acidic polysaccharide (WDP) from walnut dregs.
In vitro assays conducted using RAW264.7 cells to assess immune modulation and MAPK activation.
WDP enhanced phagocytosis in RAW264.7 cells, indicating improved immune response.
Increased nitric oxide (NO) release and elevated levels of cytokines IL-1β, IL-6, and TNF-α were observed.
WDP activated the MAPK signaling pathway, underscoring its potential as an immunomodulatory agent.

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Novel polysaccharide from walnut dregs modulates immune responses in cells, suggesting functional food potential.

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Gong et al. (2026) studied this question.

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