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June 26, 2026Angewandte Chemie

Fibers and Double‐Layered Tubes Formed From a Single Self‐Complementary DNA Oligonucleotide

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Authors

SSSo ShiraiUniversity of Electro-CommunicationsTMTetsunao MakinoUniversity of Electro-CommunicationsTKTakashi KajitaniTokyo Institute of Technology

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Implication

Demonstrates distinct fiber and tube formations from a DNA oligonucleotide, indicating new material design possibilities.

Key Points

  • The objective is to investigate how a short self-complementary DNA oligonucleotide can self-assemble into unique structures.
  • Utilized thermal annealing for DNA self-assembly
  • Varying poly(ethylene glycol) concentrations to manipulate depletion forces
  • Employed small-angle X-ray scattering to analyze structural organization
  • At lower PEG concentrations (25–30 w/v %), primarily elongated fibers formed with a single columnar hexagonal packing structure (SAXS)
  • At higher PEG concentrations (35–40 w/v %), tubular assemblies developed with differing packing densities indicated by SAXS
  • Nucleation behavior was significantly influenced by temperature and PEG concentration, demonstrating distinct morphology outcomes

Cite This Study

Shirai et al. (2026) studied this question.

synapsesocial.com/papers/6a3e16cd030ad1a9b30908f8https://doi.org/10.1002/ange.6741643
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