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June 26, 2026World Journal of Surgical Oncology0 citationsOpen Access

Triple Primary Synchronous Liver Tumors With Distinct Pathologies and Bioinformatics Insight

Triple primary synchronous liver cancer in one patient: the first case report and origin speculation through bioinformatics

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Authors

ZZZheng ZhouSHS HuTLTing Liu

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Overview

Case report shows distinct liver tumors in one patient, suggesting complex origins and treatment implications.

Key Points

  • To report a unique case of three synchronous primary liver tumors and explore their origins using bioinformatics analysis.
  • Case presentation of a 63-year-old female with a history of hepatitis B and three liver lesions
  • Preoperative assessment using multiphase MRI and gene testing to identify tumor types and mutations
  • Bioinformatics analysis to investigate clonal origins and HBV integration sites
  • Three distinct types of liver tumors were identified: HCC, ICC, and cHCC-CCA.
  • Bioinformatics analysis indicated two clonal origins with shared HBV integration sites between cHCC-CCA and ICC.
  • Hepatectomy was performed, confirming the large lesion as cHCC-CCA, while smaller lesions were HCC and ICC.

Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/6a3e16cd030ad1a9b3090937https://doi.org/10.1186/s12957-026-04470-9
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