Case report shows rare occurrence of double primary liver cancers, suggesting unique clinical implications.
INTRODUCTION: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) are the most common and second most common primary liver cancers, respectively. In contrast, double primary hepatic cancer (DPHC), the synchronous occurrence of these two tumors in different locations of the liver, is an uncommon pathology, occurring in less than 0.8% of all liver malignancies.
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Yoshimura et al. (2026) studied this question.
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