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Tandem SET/1,5-HAT reaction produces diamine derivatives from aliphatic amines, indicating a new synthesis method.
A tandem SET/1,5-HAT reaction of 2-iodobenzamides and N -benzhydryl imines for the synthesis of 1,2-diamine derivatives is described. Using super electron donor (SED) 2-azaallyl anions, single-electron transfer (SET) generates an aryl radical. A hydrogen atom transfer (HAT) from N-α- C(sp 3 )–H to the aryl radical generates alkyl radicals, which is followed by coupling with 2-azaallyl radicals to produce diamine derivatives.
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Xu et al. (2026) studied this question.
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