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This work demonstrates how a disordered region stabilizes a folded RNA-binding domain, suggesting implications for misfolding in FUS dysfunction.
, and the KK loop through a network of targeted multivalent contacts between the RGG and RRM residues. This work reveals how a disordered region stabilizes a folded RNA-binding domain, underscoring the importance of disordered-ordered interdomain coupling in shaping the folding landscape of FUS RRM. These results suggest that disruption of such interactions could destabilize the RRM fold and may contribute to misfolding-prone states relevant to FUS dysfunction.
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Rahimi et al. (2026) studied this question.
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