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June 26, 2026Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Chronology of Non-Motor Symptoms in 100 Patients with Advanced PD of 10 Years’ Duration: Pre- versus Post-Motor Period

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Authors

SVSricharan VijayakumarNational Institute of Mental Health and NeurosciencesNKNitish KambleNational Institute of Mental Health and NeurosciencesVHVikram V. HollaNational Institute of Mental Health and Neurosciences

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Implication

Cross-sectional study explores chronology of non-motor symptoms in advanced Parkinson's disease, indicating diverse symptom onset patterns.

Key Points

  • To investigate the timeline for the development of non-motor symptoms in patients with long-standing Parkinson's disease.
  • Single-centre cross-sectional study conducted from May 2023 to December 2024
  • Included 100 patients with idiopathic Parkinson's disease for at least 10 years
  • Characterized non-motor symptom evolution chronologically.
  • 63% of patients reported rapid eye movement sleep behavioural disorder (RBD) as the most frequent non-motor symptom
  • 24% of patients experienced pre-motor onset of non-motor symptoms, with RBD and constipation both at 8%
  • 70% of patients exhibited post-motor onset of non-motor symptoms, with 84% classified as brain-first subtype.

Cite This Study

Vijayakumar et al. (2026) studied this question.

synapsesocial.com/papers/6a3e1a93030ad1a9b3092f64https://doi.org/10.1017/cjn.2025.10523
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system2005 · 1,052 citations
  2. 2Higher incidence of depression preceding the onset of Parkinson's disease: A register study2003 · 345 citations
  3. 3Parkinson Disease: The Relationship Between Non-motor Symptoms and Motor Phenotype2015 · 71 citations
  4. 4Excess burden of constipation in Parkinson's disease: A pilot study2006 · 129 citations