Key result
Beta-blockers in tight mitral stenosis reduce peak oxygen consumption ~20% without improving exercise time.
Why the study?
The role of beta-blockers in symptomatic patients with tight mitral stenosis in sinus rhythm has been controversial, with treadmill exercise time yielding conflicting results.
Does beta-blocker therapy improve cardiopulmonary exercise performance in symptomatic patients with tight mitral stenosis in sinus rhythm?
Comparison
Beta-blocker (acebutalol or atenolol) vs matching placebo for one week each
Design
Randomized double-blind crossover trial
Follow-up
4 weeks
Authors
Loading...
Beta-blockade confers no cardiopulmonary exercise benefit in symptomatic tight mitral stenosis; challenges routine use and prior conflicting data.
RCT (n=19)
Double-blind
Crossover
Does beta-blocker therapy improve cardiopulmonary exercise performance in symptomatic patients with tight mitral stenosis in sinus rhythm?
Beta-blocker therapy does not improve aerobic capacity or ventilatory performance in patients with tight mitral stenosis in sinus rhythm, and adequate beta-blockade may actually impair peak oxygen consumption.
Patel et al. (1995) conducted an RCT in Mitral stenosis in sinus rhythm (n=19). Beta-blocker (acebutalol or atenolol) vs. Placebo was evaluated on Mean peak oxygen consumption. Beta-blocker therapy in patients with tight mitral stenosis did not improve exercise time, and adequate beta-blockade significantly reduced peak oxygen consumption (14.0 vs 17.5 ml/min/kg).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: