Key result
Genetic variants in NEBL (rs16921209, OR 32.22) and TUBA3C (rs17076896, OR 21.03) were significantly associated with the development of coronary artery aneurysms in patients with Kawasaki disease.
Population
157 Taiwanese patients with Kawasaki disease, 61.15% male.
Design
Case-control
Authors
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May inform future CAA risk models in KD; leaves open validation and clinical utility in larger cohorts.
Case-Control (n=157)
No
Odds Ratio: 32.22
p-value: p=7.44 × 10^-9
This genome-wide association study identified novel susceptibility genes, including NEBL and TUBA3C, that are strongly associated with the formation of coronary artery aneurysms in patients with Kawasaki disease.
Kuo et al. (2016) conducted a case-control in Kawasaki Disease (n=157). NEBL rs16921209 genetic variant vs. Absence of the genetic variant was evaluated on Coronary artery aneurysm (CAA) formation (OR 32.22, p=7.44 × 10^-9). Genetic variants in NEBL (rs16921209, OR 32.22) and TUBA3C (rs17076896, OR 21.03) were significantly associated with the development of coronary artery aneurysms in patients with Kawasaki disease.
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