Patients with pulmonary arterial hypertension exhibited higher dyspnoea scores (5.8 vs 3.8), higher ventilatory equivalents for CO2 (58 vs 44), and lower peak oxygen pulse (5.9 vs 8.7 mL/beat) than those with chronic heart failure.
Cross-Sectional (n=38)
Does the cardiopulmonary exercise testing profile differ between patients with pulmonary arterial hypertension and chronic heart failure at the same severity of functional limitation?
Despite similar functional limitation, patients with pulmonary arterial hypertension exhibit more dyspnoea, reduced ventilatory efficiency, and lower stroke volume during exercise compared to those with chronic heart failure.
Exercise capacity is reduced in pulmonary arterial hypertension and in chronic left heart failure, but it is not known whether the cardiopulmonary exercise testing profile is different in the two conditions at the same severity of functional limitation. Nineteen patients with pulmonary arterial hypertension and 19 with chronic heart failure underwent a 6-min walk test and symptom-limited maximal incremental cycle ergometry. The patients with pulmonary arterial hypertension and chronic heart failure did not differ in New York Heart Association Functional Class (mean +/- SEM 2.8 +/- 0.1 versus 2.8 +/- 0.2), 6-min walking distance (395 +/- 30 versus 419 +/- 20 m), peak work-rate, oxygen consumption, ventilation and cardiac frequency. However, patients with pulmonary arterial hypertension exhibited higher dyspnoea scores (5.8 +/- 0.6 versus 3.8 +/- 0.5) higher ventilatory equivalents for carbon dioxide (58 +/- 3 versus 44 +/- 3 at the anaerobic threshold) and lower peak oxygen pulse (5.9 +/- 0.4 versus 8.7 +/- 0.5 mL x beat(-1), or 53 +/- 4 versus 64 +/- 4% of the predicted value). It is concluded that the cardiopulmonary exercise testing profile in pulmonary arterial hypertension differs from that in chronic heart failure by showing more dyspnoea at comparable work-rates, related to greater reductions in ventilatory efficiency and stroke volume.
Deboeck et al. (Wed,) conducted a cross-sectional in Pulmonary arterial hypertension and chronic heart failure (n=38). Pulmonary arterial hypertension vs. Chronic heart failure was evaluated on Cardiopulmonary exercise testing profile (dyspnoea scores, ventilatory equivalents for CO2, peak oxygen pulse). Patients with pulmonary arterial hypertension exhibited higher dyspnoea scores (5.8 vs 3.8), higher ventilatory equivalents for CO2 (58 vs 44), and lower peak oxygen pulse (5.9 vs 8.7 mL/beat) than those with chronic heart failure.
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