Key result
Chronic mild stress in male rats induced anhedonia, elevated resting heart rate, reduced heart rate variability, and significantly attenuated sympathoexcitatory responses to hypotension.
Why the study?
Does chronic mild stress alter baroreceptor reflex function and cardiovascular regulation in a rodent model of depression?
Does chronic mild stress alter baroreceptor reflex function and cardiovascular regulation in a rodent model of depression?
Answers are grounded in this paper and cite their sources.
In a rodent model, chronic mild stress induces depression-like behavior and alters cardiovascular control, including attenuated sympathoexcitatory responses to hypotension.
Objective: There is a bidirectional relationship between mood disorders (e.g., depression) and altered cardiovascular regulation (e.g., heart disease); however, the precise causal and/or common mechanisms underlying this association are unclear. In previous studies, we have noted indications of altered sympathetic drive to the heart in rats that exhibit anhedonia, an operational sign of depression induced by subjecting the animals to a series of mild and unpredictable stressors (chronic mild stress (CMS) rodent model of depression). The purpose of the present study was to more fully characterize baroreceptor reflex function in rats with experimentally induced depression. Methods: Male, Sprague-Dawley rats were exposed to either 4 weeks of mild, unpredictable stressors (CMS group) or standard housing conditions (control group). Depression-like behavior, resting hemodynamic and cardiac parameters, and baroreceptor reflex function were investigated in all animals after the CMS period. Results: CMS produced anhedonia, evidenced by reduced sucrose intake and sucrose preference, as well as elevated resting heart rate (HR), slightly elevated blood pressure, and reduced HR variability. These animals also exhibited significantly attenuated sympathoexcitatory responses to hypotension, and an elevation of basal sympathetic nerve activity. Conclusions: These findings suggest that CMS is associated with altered sympathoexcitatory responses after baroreceptor unloading and provide further insights into potential common mechanisms underlying the association of depression and altered cardiovascular control. ANOVA = analysis of variance; CMS = chronic mild stress; DSM-IV-TR = Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision; HR = heart rate; LSNA = lumbar sympathetic nerve activity; MAP = mean arterial pressure; SEM = standard error of the mean; SDNN = standard deviation of normal-to-normal intervals.
No takes yet. Share an insight, caveat, or question.
Grippo et al. (2008) studied Depression (chronic mild stress model). Chronic mild stress (CMS) vs. Standard housing conditions was evaluated on Depression-like behavior, resting hemodynamic and cardiac parameters, and baroreceptor reflex function. Chronic mild stress in male rats induced anhedonia, elevated resting heart rate, reduced heart rate variability, and significantly attenuated sympathoexcitatory responses to hypotension.
Synapse has enriched 10 related papers. Consider them for comparative context: