Key result
Type 2 diabetic subjects with normal conventional echocardiography showed early diastolic impairment on tissue Doppler imaging compared to controls, evidenced by a reduced Ea/Aa ratio (1.00 vs 1.39, P<0.0001).
Why the study?
Does tissue Doppler imaging detect pre-clinical impairment of diastolic function in non-obese, normotensive Type 2 diabetic subjects with normal cardiac function on conventional echocardiography?
Population
40 non-obese, normotensive, uncomplicated Type 2 diabetic subjects with short duration of disease and normal…
Comparison
Tissue Doppler imaging (TDI) echocardiography vs Conventional echocardiography and healthy…
Design
Case-control
Authors
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TDI may identify subclinical diastolic impairment in early T2D with normal conventional echo; leaves open prospective validation for risk stratification.
Observational (n=60)
Does tissue Doppler imaging detect pre-clinical impairment of diastolic function in non-obese, normotensive Type 2 diabetic subjects with normal cardiac function on conventional echocardiography?
Absolute Event Rate: 1% vs 1.39%
p-value: p=<0.0001
Tissue Doppler imaging can detect early pre-clinical diastolic dysfunction in Type 2 diabetic patients who appear to have normal cardiac function on conventional echocardiography, and this impairment is associated with insulin resistance.
Bonito et al. (2005) conducted an observational in Type 2 diabetes (diabetic cardiomyopathy) (n=60). Type 2 diabetes vs. Control subjects was evaluated on Ea/Aa ratio measured by tissue Doppler imaging (p=<0.0001). Type 2 diabetic subjects with normal conventional echocardiography showed early diastolic impairment on tissue Doppler imaging compared to controls, evidenced by a reduced Ea/Aa ratio (1.00 vs 1.39, P<0.0001).
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