Effects of uninterrupted dabigatran on the intensity of anticoagulation during atrial fibrillation ablation

Figures

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  FIGURE 1. The administration schedule of DOACs during hospitalization. Group A (interrupted group), the anticoagulant medication was interrupted before the ablation. Group B (uninterrupted group), the anticoagulant medication was changed to dabigatran at a dose of 110 mg twice daily on the ablation day and was uninterrupted before the ablation. When patients took a dose of 150 mg twice daily, the administration dose was reduced to 110 mg on the ablation day. ABL, ablation; DOACs, direct oral anticoagulants

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  FIGURE 2. Flow diagram of the patient eligibility. AF, atrial fibrillation; DOACs, direct oral anticoagulants

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  FIGURE 3. Comparison of the ACT level and proportion of an achievement rate of the target ACT level (≧300 s). (A) Comparison of the ACT level and proportion of an achievement rate of the target ACT level (≧300 s) after the initial heparin injection. The initial ACT levels were significantly higher in the uninterrupted group. The proportion of an initial ACT level of more than 300 was also significantly higher in the uninterrupted group. (B) Comparison of the ACT level and proportion of an achievement rate of the target ACT level (≧300 s) after the second measurements. The ACT levels after the second measurements were significantly higher in the uninterrupted group. The percentage of ACT levels of more than 300 after the second measurements was significantly higher in the uninterrupted group. (C) Comparison of the ACT levels and proportion of the achievement rate of the target ACT level (≧300 s) during the procedure. The ACT levels during procedure were significantly higher in the uninterrupted group. The percentage of ACT levels of more than 300 during the procedure was significantly higher in the uninterrupted group. The continuous variables are shown as the mean value ± SD. ACT,…

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  FIGURE 4. Comparison of the ACT level and proportion of an achievement rate of the target ACT level (≧300 s) for AM and PM. (A) Comparison of the ACT level and proportion of an achievement rate of the target ACT level (≧300 s) after the initial heparin injection for AM and PM cases. The initial ACT levels were significantly higher in the uninterrupted group. The proportion of an initial ACT level of more than 300 was also significantly higher in the uninterrupted group. (B) Comparison of the ACT level and proportion of an achievement rate of the target ACT level (≧300 s) after the second measurements for AM and PM cases. Both were significantly higher in the uninterrupted group for AM cases. However, there are no significant difference between interrupted and uninterrupted groups for PM cases. (C) Comparison of the ACT levels and proportion of the achievement rate of the target ACT level (≧300 s) during the procedure for AM and PM cases. Both were also significantly higher in the uninterrupted group for AM cases. But these have no statistical significance between interrupted and interrupted groups for PM cases. The continuous variables are shown as the mean value ± SD. ACT, activated…

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  FIGURE 5. Changes in the mean ACT level during the procedure. The first and second ACT levels were significantly higher in uninterrupted group. The mean ACT level in the uninterrupted group was always higher than that in the interrupted group. The error bar indicates SD. Values are shown as the mean level (* < 0.05). ACT, activated clotting time