Fontan circulation was associated with markedly elevated total and selective plasma bile acids, which negatively correlated with cardiopulmonary function and hemodynamic parameters.
Case-Control
Are plasma bile acids elevated in patients with Fontan circulation compared to healthy controls and associated with worsening pathophysiology?
Plasma bile acids are significantly elevated in patients with Fontan circulation and correlate with worsening cardiopulmonary and hemodynamic physiology, suggesting a potential biomarker role.
BACKGROUND: Patients with Fontan circulation are frail and experience multisystem dysfunction including impaired exercise capacity, low resting and exercise-augmented cardiac output, and progressive liver fibrosis. However, common underlying biochemical abnormalities or disease-specific biomarkers have not been well-described. OBJECTIVES: We wish to investigate Fontan and their matched healthy subjects using a nontargeted, followed by targeted metabolomic analysis. METHODS: Patients with Fontan circulation were compared to age- and sex-matched healthy controls with regard to body composition, markers of frailty, cardiopulmonary exercise testing, and resting and exercise-augmented hemodynamics. Subsequently, the study participants underwent a nontargeted metabolomics assessment, followed by targeted plasma bile acid (BA) analysis. RESULTS: max, and had lower resting and postexercise hemodynamic parameters. Nontargeted metabolomics assessment demonstrated elevated BAs, oxylipins, and leucine metabolites in Fontan patients. Total BA as well as 17 BA components were markedly elevated in the Fontan patients. Selective BAs were negatively associated with age, degree of frailty, cardiopulmonary function, and hemodynamic parameters. CONCLUSIONS: Elevated BAs are associated with worsening Fontan physiology. These findings warrant further exploration.
Shah et al. (Sat,) conducted a case-control in Fontan circulation. Fontan circulation vs. Age- and sex-matched healthy controls was evaluated on Plasma bile acid (BA) levels and metabolomic profile. Fontan circulation was associated with markedly elevated total and selective plasma bile acids, which negatively correlated with cardiopulmonary function and hemodynamic parameters.