What is the clinical evidence from this study?

Study design: Case Report. Population: Classical Hodgkin lymphoma and right atrial thrombus (n=1). Intervention: Anticoagulation (LMWH and Apixaban). Primary outcome: Thrombus reduction and completion of chemotherapy.

What does this research mean for the field?

Anticoagulation therapy transitioning from low-molecular-weight heparin to apixaban can achieve progressive resolution of right atrial thrombosis and permit the safe completion of chemotherapy in lymphoma patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe the presentation, multimodality diagnostic assessment, and management of an asymptomatic right atrial thrombus detected prior to chemotherapy initiation in a patient with classical Hodgkin lymphoma.

June 27, 2026Frontiers in HematologyOpen Access

Right atrial thrombus in treatment-naive patient with an early-stage classical Hodgkin lymphoma: a case report and review of the literature

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Key result

LMWH transitioned to apixaban reduces right atrial thrombus and enables safe chemotherapy completion.

Why the study?

Thrombotic events detected prior to systemic treatment initiation in hematologic malignancies are uncommon, and intracardiac thrombosis is a rare and diagnostically challenging manifestation.

Population

One 21-year-old woman with newly diagnosed classical Hodgkin lymphoma and an asymptomatic right atrial mass

Design

Case report and review of the literature

Authors

AGAnna GiordanoUniversity of Padua VBValentina BodanzaUniversity of Padua FAFrancesco AngotziUniversity of Padua

Discussion

Member takes

Implication

Rare pre-treatment intracardiac thrombosis in Hodgkin lymphoma warrants clinical awareness; case reports leave open systematic incidence and management studies.

Key Points

To describe the presentation, multimodality diagnostic assessment, and management of an asymptomatic right atrial thrombus detected prior to chemotherapy initiation in a patient with classical Hodgkin lymphoma.
Clinical and diagnostic workup of a 21-year-old female presenting with newly diagnosed classical Hodgkin lymphoma and an incidental right atrial mass 13 days after peripherally inserted central catheter placement.
Transthoracic echocardiography revealed a multilobulated right atrial mass, and cardiac magnetic resonance confirmed its avascular, thrombotic nature without neoplastic infiltration.
Initial anticoagulation with low-molecular-weight heparin transitioned to apixaban yielded progressive lesion reduction and complete metabolic response on end-of-treatment PET-CT without bleeding or thromboembolism.

Study Design

Type

Case Report (n=1)

Multicenter

Structured PICO

Population

A 21-year-old woman with newly diagnosed classical Hodgkin lymphoma who developed an asymptomatic right atrial thrombus prior to chemotherapy initiation.

Intervention

Anticoagulation therapy and multimodality imaging (PET-CT, transthoracic echocardiography, cardiac magnetic resonance imaging)

Outcome

Reduction of intracardiac lesion and completion of chemotherapy without thromboembolic or hemorrhagic complications

This case highlights the utility of multimodality imaging in diagnosing right atrial thrombus in lymphoma patients and demonstrates successful management with anticoagulation.

Limitations

Absence of cardiac imaging before PICC placement, preventing determination of whether the thrombus was already present or catheter-induced.

Cite This Study

Giordano et al. (2026) conducted a case report in Classical Hodgkin lymphoma and right atrial thrombus (n=1). Anticoagulation (LMWH and Apixaban) was evaluated on Thrombus reduction and completion of chemotherapy. Anticoagulation therapy with low-molecular-weight heparin transitioned to apixaban resulted in progressive reduction of the right atrial thrombus and allowed safe completion of chemotherapy.

synapsesocial.com/papers/6a3f6772aea7db3c1953eed7 https://doi.org/10.3389/frhem.2026.1874214

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Implication

Rare pre-treatment intracardiac thrombosis in Hodgkin lymphoma warrants clinical awareness; case reports leave open systematic incidence and management studies.

Right atrial thrombus in treatment-naive patient with an early-stage classical Hodgkin lymphoma: a case report and review of the literature

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Right atrial thrombus in treatment-naive patient with an early-stage classical Hodgkin lymphoma: a case report and review of the literature

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

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