Comparative efficacy of platelet-rich plasma monotherapy versus combination therapies for knee osteoarthritis: a systematic review and network meta-analysis

Dehao Luan; Xiaonan Zhang; Z Y Zhang; Xi Man; Hai Bo

doi:10.1186/s13018-026-07042-5

June 24, 2026Journal of Orthopaedic Surgery and ResearchOpen Access

Comparative efficacy of platelet-rich plasma monotherapy versus combination therapies for knee osteoarthritis: a systematic review and network meta-analysis

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Key Points

This study aims to evaluate the efficacy of platelet-rich plasma (PRP) monotherapy versus combination therapies for knee osteoarthritis.
Conducted a systematic review and network meta-analysis (NMA) in adults with knee osteoarthritis.
Used the Cochrane RoB 2 tool for risk of bias assessment and Stata 17.0 for data analysis.
Primary outcomes included changes in WOMAC total score and VAS pain score.
PRP alone did not show significant differences compared to other treatments (MD = -0.15, 95% CI -1.87 to 1.57).
PRP + HA was ranked highest for VAS pain and second for WOMAC function.
No significant publication bias was detected in the analysis.

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Implication

Systematic review and network meta-analysis compares PRP monotherapy and combination therapies for knee osteoarthritis, suggesting PRP+HA shows better outcomes.

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Cite This Study

Luan et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6772aea7db3c1953eef2 https://doi.org/10.1186/s13018-026-07042-5

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Comparative efficacy of platelet-rich plasma monotherapy versus combination therapies for knee osteoarthritis: a systematic review and network meta-analysis

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

Comparative efficacy of platelet-rich plasma monotherapy versus combination therapies for knee osteoarthritis: a systematic review and network meta-analysis

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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