Observational findings indicate varying outcomes in eyes with ERM versus without, suggesting a need for re-evaluation in DME treatment strategies.
in long-term outcomes between eyes with and without ERM, particularly in terms of DRIL and EZ-ELM integrity?Meanwhile, a few methodological clarifications could further strengthen the interpretation of the findings: (1) It was stated that bilateral eyes were included in the analysis; clarifying whether a statistical approach was used for inter-eye correlation (two eyes from the same patient) would enhance the robustness of the results.(2) As two independent researchers evaluated the OCT findings, reporting inter-observer agreement (kappa/ intraclass correlation coefficient) would be beneficial for reproducibility, especially for parameters such as DRIL and EZ-ELM integrity.(3) Finally, compared with the MEAD study, the cataract surgery rate in this cohort was remarkably high (97%), indicating that cataract development in patients scheduled for DEX implant monotherapy should be considered an inevitable "stage" of the treatment rather than a "side effect." 5 Was pseudophakic subgroup analysis or sensitivity analysis considered to mitigate the impact of lens status when interpreting visual gains over time?The data shared by the authors will raise the need to re-evaluate the anti-VEGF-prioritized treatment paradigm in DME management for selected treatment-naïve cases.
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Karataş et al. (2026) studied this question.
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