Comparative Evaluation of Abbott ARCHITECT and Roche Elecsys Automated HBsAg Confirmatory Neutralization Assays in Low-Level Reactive Samples

significantly with the widespread adoption of automated chemiluminescent immunoassays, which offer high sensitivity and rapid turnaround times suitable for high-volume testing in clinical laboratories [2, 3].However, the increased sensitivity of these automated platforms can compromise specificity, particularly in low-prevalence populations, such as asymptomatic individuals undergoing routine health checkups [4].A persistent challenge in laboratory medicine is the detection of samples with low-level reactivity-typically defined as a signal-to-cutoff (S/CO) ratio between 1.0 and 10.0.Within this range, a significant proportion of reactive results are biological false positives caused by non-specific interference, heterophilic antibodies, or sample matrix effects rather than true viral infection [5, 6].To mitigate the risk of misdiagnosis and unnecessary medical Hepatitis B surface antigen (HBsAg) is the principal serological marker for the diagnosis of acute and chronic hepatitis B virus (HBV) infection [1].Detection methods for HBsAg have evolved 저수준 반응성 검체에서 Abbott Architect와 Roche Elecsys 자동화 HBsAg 확인 중화 검사법의 비교 평가