What question did this study set out to answer?

To assess the effectiveness of thoracic paravertebral block using liposomal bupivacaine compared to ropivacaine in postoperative pain management for lung surgery.

June 27, 2026Annals of MedicineOpen Access

Thoracic paravertebral block with different doses of liposomal bupivacaine versus ropivacaine for postoperative analgesia in single-port thoracoscopic lung surgery: a randomized clinical trial

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Authors

LRLiyuan RenFirst Affiliated Hospital of Zhengzhou University ZNZhenhua NanFirst Affiliated Hospital of Zhengzhou University YLYanshuang LiBeijing Biocytogen (China)

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Implication

Randomized trial evaluates analgesic efficacy in lung surgery, suggesting similar outcomes for interventions.

Key Points

To assess the effectiveness of thoracic paravertebral block using liposomal bupivacaine compared to ropivacaine in postoperative pain management for lung surgery.
Randomized clinical trial with 105 patients assigned to three groups: low-dose LB, high-dose LB, or ropivacaine.
All groups received ultrasound-guided thoracic paravertebral block at the T5/6 level before surgery.
Primary outcome was the area under the curve of pain scores from 1 to 72 hours postoperatively.
AUC-aNRS was lower in the high-dose LB group compared to low-dose LB (p = 0.0071), but not significantly different from ropivacaine.
Cumulative opioid consumption was significantly lower in the high-dose LB group compared to low-dose LB (p < 0.017), but not versus ropivacaine.
No significant differences in AUC-rNRS or postoperative recovery and adverse events (p > 0.05).

Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6772aea7db3c1953ef6d https://doi.org/10.1080/07853890.2026.2687941

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Thoracic paravertebral block with different doses of liposomal bupivacaine versus ropivacaine for postoperative analgesia in single-port thoracoscopic lung surgery: a randomized clinical trial

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Key Points

Cite This Study

Thoracic paravertebral block with different doses of liposomal bupivacaine versus ropivacaine for postoperative analgesia in single-port thoracoscopic lung surgery: a randomized clinical trial

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Implication

Key Points

Cite This Study

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