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June 27, 2026Biomedicine & PharmacotherapyOpen Access

CGRP–uric acid axis in migraine: A redox–inflammatory framework linking neurovascular signaling and metabolic regulation

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Authors

CLChien‐Lin LuYCYu-Chen ChengKLKuo‐Cheng Lu

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Overview

This review proposes a CGRP-UA framework linking redox and inflammatory processes in migraine, suggesting future research directions.

Key Points

  • To explore the relationship between CGRP signaling and uric acid in migraine within a redox-inflammatory framework.
  • Review of current literature on CGRP signaling, oxidative stress, and uric acid metabolism.
  • Assessment of the roles of reactive oxygen species and inflammasome activation in migraine pathology.
  • CGRP-associated oxidative stress may lead to neuronal sensitization and neurogenic inflammation.
  • Uric acid can act as both an antioxidant and a pro-inflammatory agent, depending on its cellular context.
  • The proposed framework highlights interactions between CGRP, oxidative stress, and downstream immune responses.

Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67aaaea7db3c1953f0c9https://doi.org/10.1016/j.biopha.2026.119709
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